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Z-farnesyl diphosphate synthase

In enzymology, a Z-farnesyl diphosphate synthase (EC 2.5.1.68) is an enzyme that catalyzes the chemical reaction

geranyl diphosphate + isopentenyl diphosphate diphosphate + (2Z,6E)-farnesyl diphosphate

Thus, the two substrates of this enzyme are geranyl diphosphate and isopentenyl diphosphate, whereas its two products are diphosphate and (2Z,6E)-farnesyl diphosphate.

This enzyme belongs to the family of transferases, specifically those transferring aryl or alkyl groups other than methyl groups. The systematic name of this enzyme class is geranyl-diphosphate:isopentenyl-diphosphate geranylcistransferase. This enzyme is also called (Z)-farnesyl diphosphate synthase.

References

• IUBMB entry for 2.5.1.68
• BRENDA references for 2.5.1.68 (Recommended.)
• PubMed references for 2.5.1.68
• PubMed Central references for 2.5.1.68
• Google Scholar references for 2.5.1.68
• F, Bertini S, Brennan PJ, Crick DC (2001). "Purification, enzymatic characterization, and inhibition of the Z-farnesyl diphosphate synthase from Mycobacterium tuberculosis". J. Biol. Chem. 276: 11624–30. PMID 11152452. 

External links

• IUBMB entry for 2.5.1.68

• KEGG entry for 2.5.1.68

• BRENDA entry for 2.5.1.68

• NiceZyme view of 2.5.1.68

• EC2PDB: PDB structures for 2.5.1.68

• PRIAM entry for 2.5.1.68

• PUMA2 entry for 2.5.1.68

• IntEnz: Integrated Enzyme entry for 2.5.1.68

• MetaCyc entry for 2.5.1.68

• Atomic-resolution structures of enzymes belonging to this class