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S-alkylcysteine lyase

In enzymology, a S-alkylcysteine lyase (EC 4.4.1.6) is an enzyme that catalyzes the chemical reaction

an S-alkyl-L-cysteine + H₂O an alkyl thiol + NH₃ + pyruvate

Thus, the two substrates of this enzyme are S-alkyl-L-cysteine and H₂O, whereas its 3 products are alkyl thiol, NH₃, and pyruvate.

This enzyme belongs to the family of lyases, specifically the class of carbon-sulfur lyases. The systematic name of this enzyme class is S-alkyl-L-cysteine alkyl-thiol-lyase (deaminating; pyruvate-forming). Other names in common use include S-alkylcysteinase, alkylcysteine lyase, S-alkyl-L-cysteine sulfoxide lyase, S-alkyl-L-cysteine lyase, S-alkyl-L-cysteinase, alkyl cysteine lyase, and S-alkyl-L-cysteine alkylthiol-lyase (deaminating). It employs one cofactor, pyridoxal phosphate.

References

• IUBMB entry for 4.4.1.6
• BRENDA references for 4.4.1.6 (Recommended.)
• PubMed references for 4.4.1.6
• PubMed Central references for 4.4.1.6
• Google Scholar references for 4.4.1.6
• Nomura J, Nishizuka Y and Hayaishi O (1963). "S-Alkylcysteinase: enzymatic cleavage of S-methyl-L-cysteine and its sulfoxide". J. Biol. Chem. 238: 1441–1446. 

External links

The CAS registry number for this enzyme class is 62213-27-8.

• IUBMB entry for 4.4.1.6

• KEGG entry for 4.4.1.6

• BRENDA entry for 4.4.1.6

• NiceZyme view of 4.4.1.6

• EC2PDB: PDB structures for 4.4.1.6

• PRIAM entry for 4.4.1.6

• PUMA2 entry for 4.4.1.6

• IntEnz: Integrated Enzyme entry for 4.4.1.6

• MetaCyc entry for 4.4.1.6

• Atomic-resolution structures of enzymes belonging to this class

Gene Ontology (GO) codes

• EGO entry for GO code 0050271: S-alkylcysteine lyase

• AMIGO entry for GO code 0050271: S-alkylcysteine lyase