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S-adenosylhomocysteine deaminase

In enzymology, a S-adenosylhomocysteine deaminase (EC 3.5.4.28) is an enzyme that catalyzes the chemical reaction

S-adenosyl-L-homocysteine + H₂O S-inosyl-L-homocysteine + NH₃

Thus, the two substrates of this enzyme are S-adenosyl-L-homocysteine and H₂O, whereas its two products are S-inosyl-L-homocysteine and NH₃.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in cyclic amidines. The systematic name of this enzyme class is S-adenosyl-L-homocysteine aminohydrolase. This enzyme is also called adenosylhomocysteine deaminase.

References

• IUBMB entry for 3.5.4.28
• BRENDA references for 3.5.4.28 (Recommended.)
• PubMed references for 3.5.4.28
• PubMed Central references for 3.5.4.28
• Google Scholar references for 3.5.4.28
• Zulty JJ, Speedie MK (1989). "Purification and characterization of S-adenosylhomocysteine deaminase from streptonigrin-producing Streptomyces flocculus". J. Bacteriol. 171: 6840–4. PMID 2592350. 

External links

The CAS registry number for this enzyme class is 125149-24-8.

• IUBMB entry for 3.5.4.28

• KEGG entry for 3.5.4.28

• BRENDA entry for 3.5.4.28

• NiceZyme view of 3.5.4.28

• EC2PDB: PDB structures for 3.5.4.28

• PRIAM entry for 3.5.4.28

• PUMA2 entry for 3.5.4.28

• IntEnz: Integrated Enzyme entry for 3.5.4.28

• MetaCyc entry for 3.5.4.28

• Atomic-resolution structures of enzymes belonging to this class

Gene Ontology (GO) codes

• EGO entry for GO code 0050270: S-adenosylhomocysteine deaminase

• AMIGO entry for GO code 0050270: S-adenosylhomocysteine deaminase