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S-(hydroxymethyl)glutathione synthase

In enzymology, a S-(hydroxymethyl)glutathione synthase (EC 4.4.1.22) is an enzyme that catalyzes the chemical reaction

S-(hydroxymethyl)glutathione glutathione + formaldehyde

Hence, this enzyme has one substrate, S-(hydroxymethyl)glutathione, and two products, glutathione and formaldehyde.

This enzyme belongs to the family of lyases, specifically the class of carbon-sulfur lyases. The systematic name of this enzyme class is S-(hydroxymethyl)glutathione formaldehyde-lyase (glutathione-forming). Other names in common use include glutathione-dependent formaldehyde-activating enzyme, Gfa, and S-(hydroxymethyl)glutathione formaldehyde-lyase. This enzyme participates in methane metabolism.

References

• IUBMB entry for 4.4.1.22
• BRENDA references for 4.4.1.22 (Recommended.)
• PubMed references for 4.4.1.22
• PubMed Central references for 4.4.1.22
• Google Scholar references for 4.4.1.22
• Goenrich M, Bartoschek S, Hagemeier CH, Griesinger C, Vorholt JA (2002). "A glutathione-dependent formaldehyde-activating enzyme (Gfa) from Paracoccus denitrificans detected and purified via two-dimensional proton exchange NMR spectroscopy". J. Biol. Chem. 277: 3069–72. doi:10.1074/jbc.C100579200. PMID 11741920. 

External links

• IUBMB entry for 4.4.1.22

• KEGG entry for 4.4.1.22

• BRENDA entry for 4.4.1.22

• NiceZyme view of 4.4.1.22

• EC2PDB: PDB structures for 4.4.1.22

• PRIAM entry for 4.4.1.22

• PUMA2 entry for 4.4.1.22

• IntEnz: Integrated Enzyme entry for 4.4.1.22

• MetaCyc entry for 4.4.1.22

• Atomic-resolution structures of enzymes belonging to this class

Gene Ontology (GO) codes

• EGO entry for GO code 0051907: S-(hydroxymethyl)glutathione synthase

• AMIGO entry for GO code 0051907: S-(hydroxymethyl)glutathione synthase