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P-type ATPase

P-type (or E1-E2-type) ATPases constitute a superfamily of cation transport enzymes, present both in prokaryota and eukaryota, whose members mediate membrane flux of all common biologically relevant cations^[1]. The ATPases, that form an aspartyl phosphate intermediate in the course of ATP hydrolysis, can be divided into 4 major groups^[2]:

• (1) Ca²⁺-transporting ATPases;
• (2) Na⁺/K⁺- and gastric H⁺/K⁺-transporting ATPases;
• (3) Plasma membrane H⁺-transporting ATPases (proton pumps) of plants, fungi and lower eukaryotes; and
• (4) all bacterial P-type ATPases, except the Mg²⁺-ATPase of Salmonella typhimurium, which is more similar to the eukaryotic sequences.

Human proteins containing this domain

• Na+/K+ transporting: ATP1A1, ATP1A2, ATP1A3, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP1B4
• Ca++ transporting: ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, ATP2C1
• Cu++ transporting: ATP7A (see also ATP7A), ATP7B (see also ATP7B)
• Class I, type 8: ATP8A1, ATP8B1, ATP8B2, ATP8B3, ATP8B4
• Class II, type 9: ATP9A, ATP9B
• Class V, type 10: ATP10A, ATP10B, ATP10D
• Class VI, type 11: ATP11A, ATP11B, ATP11C
• H+/K+ transporting, nongastric: ATP12A
• type 13: ATP13A1, ATP13A2, ATP13A3, ATP13A4, ATP13A5
• ATP2C2;
• ATP4A;
• KIAA0195

See also

• Hydrogen potassium ATPase

References