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N-isopropylammelide isopropylaminohydrolase

In enzymology, a N-isopropylammelide isopropylaminohydrolase (EC 3.5.99.4) is an enzyme that catalyzes the chemical reaction

N-isopropylammelide + H₂O cyanuric acid + isopropylamine

Thus, the two substrates of this enzyme are N-isopropylammelide and H₂O, whereas its two products are cyanuric acid and isopropylamine.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in compounds that have not been otherwise categorized within EC number 3.5. The systematic name of this enzyme class is N-isopropylammelide isopropylaminohydrolase. This enzyme is also called AtzC. This enzyme participates in atrazine degradation.

Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 2QT3.

References

• IUBMB entry for 3.5.99.4
• BRENDA references for 3.5.99.4 (Recommended.)
• PubMed references for 3.5.99.4
• PubMed Central references for 3.5.99.4
• Google Scholar references for 3.5.99.4
• Sadowsky MJ, Tong Z, de Souza M, Wackett LP (1998). "AtzC is a new member of the amidohydrolase protein superfamily and is homologous to other atrazine-metabolizing enzymes". J. Bacteriol. 180: 152–8. PMID 9422605. 

External links

• IUBMB entry for 3.5.99.4

• KEGG entry for 3.5.99.4

• BRENDA entry for 3.5.99.4

• NiceZyme view of 3.5.99.4

• EC2PDB: PDB structures for 3.5.99.4

• PRIAM entry for 3.5.99.4

• PUMA2 entry for 3.5.99.4

• IntEnz: Integrated Enzyme entry for 3.5.99.4

• MetaCyc entry for 3.5.99.4

• Atomic-resolution structures of enzymes belonging to this class

Gene Ontology (GO) codes

• EGO entry for GO code 0018764: N-isopropylammelide isopropylaminohydrolase

• AMIGO entry for GO code 0018764: N-isopropylammelide isopropylaminohydrolase