Home › Multilingual Archive Index › N-hydroxyarylamine O-acetyltransferase

N-hydroxyarylamine O-acetyltransferase

In enzymology, a N-hydroxyarylamine O-acetyltransferase (EC 2.3.1.118) is an enzyme that catalyzes the chemical reaction

acetyl-CoA + an N-hydroxyarylamine CoA + an N-acetoxyarylamine

Thus, the two substrates of this enzyme are acetyl-CoA and N-hydroxyarylamine, whereas its two products are CoA and N-acetoxyarylamine.

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is acetyl-CoA:N-hydroxyarylamine O-acetyltransferase. Other names in common use include arylhydroxamate N,O-acetyltransferase, arylamine N-acetyltransferase, and N-hydroxy-2-aminofluorene-O-acetyltransferase.

Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 1E2T.

References

• IUBMB entry for 2.3.1.118
• BRENDA references for 2.3.1.118 (Recommended.)
• PubMed references for 2.3.1.118
• PubMed Central references for 2.3.1.118
• Google Scholar references for 2.3.1.118
• Saito K, Shinohara A, Kamataki T, Kato R (Tokyo). "N-hydroxyarylamine O-acetyltransferase in hamster liver: identity with arylhydroxamic acid N,O-acetyltransferase and arylamine N-acetyltransferase". J. Biochem.: 1689–97. PMID 3745141. 

External links

The CAS registry number for this enzyme class is 100984-92-7.

• IUBMB entry for 2.3.1.118

• KEGG entry for 2.3.1.118

• BRENDA entry for 2.3.1.118

• NiceZyme view of 2.3.1.118

• EC2PDB: PDB structures for 2.3.1.118

• PRIAM entry for 2.3.1.118

• PUMA2 entry for 2.3.1.118

• IntEnz: Integrated Enzyme entry for 2.3.1.118

• MetaCyc entry for 2.3.1.118

• Atomic-resolution structures of enzymes belonging to this class

Gene Ontology (GO) codes

• EGO entry for GO code 0046990: N-hydroxyarylamine O-acetyltransferase

• AMIGO entry for GO code 0046990: N-hydroxyarylamine O-acetyltransferase