N-acetylglucosamine kinase

In enzymology, a N-acetylglucosamine kinase (EC 2.7.1.59) is an enzyme that catalyzes the chemical reaction

ATP + N-acetyl-D-glucosamine ADP + N-acetyl-D-glucosamine 6-phosphate

Thus, the two substrates of this enzyme are ATP and N-acetyl-D-glucosamine, whereas its two products are ADP and N-acetyl-D-glucosamine 6-phosphate.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor. The systematic name of this enzyme class is ATP:N-acetyl-D-glucosamine 6-phosphotransferase. Other names in common use include acetylglucosamine kinase (phosphorylating), ATP:2-acetylamino-2-deoxy-D-glucose 6-phosphotransferase, 2-acetylamino-2-deoxy-D-glucose kinase, and acetylaminodeoxyglucokinase. This enzyme participates in glutamate metabolism and aminosugars metabolism.

1 Structural studies
2 References
3 External links
- 3.1 Gene Ontology (GO) codes

Structural studies

As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes 2CH5, 2CH6, and 2HOE.

References

IUBMB entry for 2.7.1.59
BRENDA references for 2.7.1.59 (Recommended.)
PubMed references for 2.7.1.59
PubMed Central references for 2.7.1.59
Google Scholar references for 2.7.1.59
Asensio C and Ruiz-Amil M (1966). "N-Acetyl-D-glucosamine kinase. II. Escherichia coli". Methods Enzymol. 9: 421–425.
Barkulis SS (1966). "N-Acetyl-D-glucosamine kinase. I. Streptococcus pyrogenes". Methods Enzymol. 9: 415–420.
Datta A (1970). "Studies on hog spleen N-acetylglucosamine kinase. I. Purification and properties of N-acetylglucosamine kinase". Biochim. Biophys. Acta. 220: 51–60. PMID 4319609.