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N-acetylglucosamine deacetylase

In enzymology, a N-acetylglucosamine deacetylase (EC 3.5.1.33) is an enzyme that catalyzes the chemical reaction

N-acetyl-D-glucosamine + H₂O D-glucosamine + acetate

Thus, the two substrates of this enzyme are N-acetyl-D-glucosamine and H₂O, whereas its two products are D-glucosamine and acetate.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in linear amides. The systematic name of this enzyme class is N-acetyl-D-glucosamine amidohydrolase. Other names in common use include acetylaminodeoxyglucose acetylhydrolase, and N-acetyl-D-glucosaminyl N-deacetylase. This enzyme participates in aminosugars metabolism.

Structural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 2C1G and 2C1I.

References

• IUBMB entry for 3.5.1.33
• BRENDA references for 3.5.1.33 (Recommended.)
• PubMed references for 3.5.1.33
• PubMed Central references for 3.5.1.33
• Google Scholar references for 3.5.1.33
• Roseman S (1957). "Glucosamine metabolism. I. N-Acetylglucosamine deacetylase". J. Biol. Chem. 226: 115–123. 

External links

The CAS registry number for this enzyme class is 9012-32-2.

• IUBMB entry for 3.5.1.33

• KEGG entry for 3.5.1.33

• BRENDA entry for 3.5.1.33

• NiceZyme view of 3.5.1.33

• EC2PDB: PDB structures for 3.5.1.33

• PRIAM entry for 3.5.1.33

• PUMA2 entry for 3.5.1.33

• IntEnz: Integrated Enzyme entry for 3.5.1.33

• MetaCyc entry for 3.5.1.33

• Atomic-resolution structures of enzymes belonging to this class

Gene Ontology (GO) codes

• EGO entry for GO code 0050119: N-acetylglucosamine deacetylase

• AMIGO entry for GO code 0050119: N-acetylglucosamine deacetylase