L-lysine oxidase

In enzymology, a L-lysine oxidase (EC 1.4.3.14) is an enzyme that catalyzes the chemical reaction

L-lysine + O₂ + H₂O 6-amino-2-oxohexanoate + NH₃ + H₂O₂

The 3 substrates of this enzyme are L-lysine, O₂, and H₂O, whereas its 3 products are 6-amino-2-oxohexanoate, NH₃, and H₂O₂.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH2 group of donors with oxygen as acceptor. The systematic name of this enzyme class is L-lysine:oxygen 2-oxidoreductase (deaminating). Other names in common use include L-lysine alpha-oxidase, and L-lysyl-alpha-oxidase. This enzyme participates in lysine degradation.

References

IUBMB entry for 1.4.3.14
BRENDA references for 1.4.3.14 (Recommended.)
PubMed references for 1.4.3.14
PubMed Central references for 1.4.3.14
Google Scholar references for 1.4.3.14
Kusakabe H, Kodama K, Kuninaka A, Yoshino H, Misono H, Soda K (1980). "A new antitumor enzyme, L-lysine alpha-oxidase from Trichoderma viride. Purification and enzymological properties". J. Biol. Chem. 255: 976–81. PMID 6101334.
Lukasheva EV, Berezov TT (Mosc). "L-Lysine alpha-oxidase: physicochemical and biological properties". B Biochemistry.: 1152–8. PMID 12460113.