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L-erythro-3,5-diaminohexanoate dehydrogenase

In enzymology, a L-erythro-3,5-diaminohexanoate dehydrogenase (EC 1.4.1.11) is an enzyme that catalyzes the chemical reaction

L-erythro-3,5-diaminohexanoate + H₂O + NAD⁺ (S)-5-amino-3-oxohexanoate + NH₃ + NADH + H⁺

The 3 substrates of this enzyme are L-erythro-3,5-diaminohexanoate, H₂O, and NAD⁺, whereas its 4 products are (S)-5-amino-3-oxohexanoate, NH₃, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH2 group of donors with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is L-erythro-3,5-diaminohexanoate:NAD+ oxidoreductase (deaminating). This enzyme is also called L-3,5-diaminohexanoate dehydrogenase. This enzyme participates in lysine degradation.

References

• IUBMB entry for 1.4.1.11
• BRENDA references for 1.4.1.11 (Recommended.)
• PubMed references for 1.4.1.11
• PubMed Central references for 1.4.1.11
• Google Scholar references for 1.4.1.11
• Baker JJ, Jeng I, Barker HA (1972). "Purification and properties of L-erythro-3,5-diaminohexanoate dehydrogenase from a lysine-fermenting Clostridium". J. Biol. Chem. 247: 7724–34. PMID 4344229. 

External links

The CAS registry number for this enzyme class is 37377-90-5.

• IUBMB entry for 1.4.1.11

• KEGG entry for 1.4.1.11

• BRENDA entry for 1.4.1.11

• NiceZyme view of 1.4.1.11

• EC2PDB: PDB structures for 1.4.1.11

• PRIAM entry for 1.4.1.11

• PUMA2 entry for 1.4.1.11

• IntEnz: Integrated Enzyme entry for 1.4.1.11

• MetaCyc entry for 1.4.1.11

• Atomic-resolution structures of enzymes belonging to this class

Gene Ontology (GO) codes

• EGO entry for GO code 0047124: L-erythro-3,5-diaminohexanoate dehydrogenase

• AMIGO entry for GO code 0047124: L-erythro-3,5-diaminohexanoate dehydrogenase