G cell

In anatomy, the G cell is a type of cell in the stomach that secretes gastrin.^[1] It works in conjunction with gastric chief cells and parietal cells.

G cells are found deep with the gastric glands of the stomach antrum, and occasionally in the pancreas.^[2]

The vagus nerve innervates the G cells.

Gastrin-releasing peptide is released by the post-ganglionic fibers of the vagus nerve onto G cells during parasympathetic stimulation.

Gastrin-releasing peptide, as well as the presence of amino acids in the stomach, stimulate the release of gastrin from the G cells. Gastrin stimulates enterochromaffin cells to release histamine.

Gastrin also targets parietal cells.

The increase of histamine and the direct stimulation by gastrin, cause parietal cells to increase HCl secretion in the stomach.

References

^ Diagram at gerd.com
^ iv_1/g/G_cell article at GE's Medcyclopaedia

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v • d • e Digestive system, physiology: gastrointestinal physiology

Enteric nervous system	Meissner's plexus - Auerbach's plexus

Exocrine	Chief cells (Pepsinogen) - Parietal cells (Gastric acid, Intrinsic factor) - Goblet cells (Mucus)

Endocrine/paracrine	G cells (gastrin), D cells (somatostatin) - ECL cells (Histamine) - enterogastrone: I cells (CCK), K cells (GIP), S cells (secretin), Enteroendocrine cells

Border	Brunner's glands - Paneth cells - Enterocytes

Fluids	Saliva - Bile - Intestinal juice - Gastric juice - Pancreatic juice

Processes	Swallowing - Vomiting - Peristalsis (Interstitial cell of Cajal) - Migrating motor complex - Borborygmus - Gastrocolic reflex - Segmentation contractions - Defecation

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