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D(-)-tartrate dehydratase

In enzymology, a D(-)-tartrate dehydratase (EC 4.2.1.81) is an enzyme that catalyzes the chemical reaction

(S,S)-tartrate oxaloacetate + H₂O

Hence, this enzyme has one substrate, (S,S)-tartrate, and two products, oxaloacetate and H₂O.

This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is (S,S)-tartrate hydro-lyase (oxaloacetate-forming). Other names in common use include D-tartrate dehydratase, and (S,S)-tartrate hydro-lyase. It has 2 cofactors: iron, and Manganese.

Structural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 2DW6 and 2DW7.

References

• IUBMB entry for 4.2.1.81
• BRENDA references for 4.2.1.81 (Recommended.)
• PubMed references for 4.2.1.81
• PubMed Central references for 4.2.1.81
• Google Scholar references for 4.2.1.81
• Rode H, Giffhorn F (1982). "D-(--)-tartrate dehydratase of Rhodopseudomonas sphaeroides: purification, characterization, and application to enzymatic determination of D-(--)-tartrate". J. Bacteriol. 150: 1061–8. PMID 6978882. 
• Rode H, Giffhorn F (1982). "Ferrous- or cobalt ion-dependent D-(-)-tartrate dehydratase of pseudomonads: purification and properties". J. Bacteriol. 151: 1602–4. PMID 7107563. 

External links

The CAS registry number for this enzyme class is 82532-88-5.

• IUBMB entry for 4.2.1.81

• KEGG entry for 4.2.1.81

• BRENDA entry for 4.2.1.81

• NiceZyme view of 4.2.1.81

• EC2PDB: PDB structures for 4.2.1.81

• PRIAM entry for 4.2.1.81

• PUMA2 entry for 4.2.1.81

• IntEnz: Integrated Enzyme entry for 4.2.1.81

• MetaCyc entry for 4.2.1.81

• Atomic-resolution structures of enzymes belonging to this class

Gene Ontology (GO) codes

• EGO entry for GO code 0047808: D(-)-tartrate dehydratase

• AMIGO entry for GO code 0047808: D(-)-tartrate dehydratase