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90Y-DOTA-biotin

90Y-DOTA-biotin is a radioactive substance (yttrium-90) joined by a large chemical link (DOTA) to biotin, a vitamin. It is often used in pretargeted radioimmunotherapy, especially in cancer research.

References

  • Domingo RJ, Reilly RM (2000). "Pre-targeted radioimmunotherapy of human colon cancer xenografts in athymic mice using streptavidin-CC49 monoclonal antibody and 90Y-DOTA-biotin". Nuclear medicine communications 21 (1): 89–96. doi:10.1097/00006231-200001000-00015. PMID 10717908. 
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