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6-oxohexanoate dehydrogenase

In enzymology, a 6-oxohexanoate dehydrogenase (EC 1.2.1.63) is an enzyme that catalyzes the chemical reaction

6-oxohexanoate + NADP⁺ + H₂O adipate + NADPH + 2 H⁺

The 3 substrates of this enzyme are 6-oxohexanoate, NADP⁺, and H₂O, whereas its 3 products are adipate, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 6-oxohexanoate:NADP+ oxidoreductase. This enzyme participates in caprolactam degradation.

References

• IUBMB entry for 1.2.1.63
• BRENDA references for 1.2.1.63 (Recommended.)
• PubMed references for 1.2.1.63
• PubMed Central references for 1.2.1.63
• Google Scholar references for 1.2.1.63
• Davey JF, Trudgill PW (1977). "The metabolism of trans-cyclohexan-1,2-diol by an Acinetobacter species". Eur. J. Biochem. 74: 115–27. doi:10.1111/j.1432-1033.1977.tb11373.x. PMID 856571. 
• Donoghue NA, Trudgill PW (1975). "The metabolism of cyclohexanol by Acinetobacter NCIB 9871". Eur. J. Biochem. 60: 1–7. doi:10.1111/j.1432-1033.1975.tb20968.x. PMID 1261. 

External links

• IUBMB entry for 1.2.1.63

• KEGG entry for 1.2.1.63

• BRENDA entry for 1.2.1.63

• NiceZyme view of 1.2.1.63

• EC2PDB: PDB structures for 1.2.1.63

• PRIAM entry for 1.2.1.63

• PUMA2 entry for 1.2.1.63

• IntEnz: Integrated Enzyme entry for 1.2.1.63

• MetaCyc entry for 1.2.1.63

• Atomic-resolution structures of enzymes belonging to this class

Gene Ontology (GO) codes

• EGO entry for GO code 0018483: 6-oxohexanoate dehydrogenase

• AMIGO entry for GO code 0018483: 6-oxohexanoate dehydrogenase