6-carboxyhexanoate-CoA ligase

In enzymology, a 6-carboxyhexanoate-CoA ligase (EC 6.2.1.14) is an enzyme that catalyzes the chemical reaction

ATP + 6-carboxyhexanoate + CoA AMP + diphosphate + 6-carboxyhexanoyl-CoA

The 3 substrates of this enzyme are ATP, 6-carboxyhexanoate, and CoA, whereas its 3 products are AMP, diphosphate, and 6-carboxyhexanoyl-CoA.

This enzyme belongs to the family of ligases, specifically those forming carbon-sulfur bonds as acid-thiol ligases. The systematic name of this enzyme class is 6-carboxyhexanoate:CoA ligase (AMP-forming). Other names in common use include 6-carboxyhexanoyl-CoA synthetase, and pimelyl-CoA synthetase. This enzyme participates in biotin metabolism.

References

IUBMB entry for 6.2.1.14
BRENDA references for 6.2.1.14 (Recommended.)
PubMed references for 6.2.1.14
PubMed Central references for 6.2.1.14
Google Scholar references for 6.2.1.14
Izumi Y, Morita H, Sato K, Tani Y, Ogata K (1972). "Synthesis of biotin-vitamers from pimelic acid and coenzyme A by cell-free extracts of various bacteria". Biochim. Biophys. Acta. 264: 210–3. PMID 4623286.
Izumi Y, Morita H, Tani Y and Ogata K (1974). "The pimelyl-CoA synthetase responsible for the first step in biotin biosynthesis by microorganisms". Agric. Biol. Chem. 38: 2257–2262.