5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase

In enzymology, a 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase (EC 4.1.1.68) is an enzyme that catalyzes the chemical reaction

5-oxopent-3-ene-1,2,5-tricarboxylate 2-oxohept-3-enedioate + CO₂

Hence, this enzyme has one substrate, 5-oxopent-3-ene-1,2,5-tricarboxylate, and two products, 2-oxohept-3-enedioate and CO₂.

This enzyme belongs to the family of lyases, specifically the carboxy-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is 5-oxopent-3-ene-1,2,5-tricarboxylate carboxy-lyase (2-oxohept-3-enedioate-forming). Other names in common use include 5-carboxymethyl-2-oxo-hex-3-ene-1,6-dioate decarboxylase, and 5-oxopent-3-ene-1,2,5-tricarboxylate carboxy-lyase. This enzyme participates in tyrosine metabolism.

1 Structural studies
2 References
3 External links
- 3.1 Gene Ontology (GO) codes

Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 1I7O.

References

IUBMB entry for 4.1.1.68
BRENDA references for 4.1.1.68 (Recommended.)
PubMed references for 4.1.1.68
PubMed Central references for 4.1.1.68
Google Scholar references for 4.1.1.68
Garrido-Pertierra A and Cooper RA (1981). "Identification and purification of distinct isomerase and decarboxylase enzymes involved in the 4-hydroxyphenylacetate pathway of Escherichia coli". Eur. J. Biochem. 117: 581–584.