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5-carboxymethyl-2-hydroxymuconate Delta-isomerase

In enzymology, a 5-carboxymethyl-2-hydroxymuconate Delta-isomerase (EC 5.3.3.10) is an enzyme that catalyzes the chemical reaction

5-carboxymethyl-2-hydroxymuconate 5-carboxy-2-oxohept-3-enedioate

Hence, this enzyme has one substrate, 5-carboxymethyl-2-hydroxymuconate, and one product, 5-carboxy-2-oxohept-3-enedioate.

This enzyme belongs to the family of isomerases, specifically those intramolecular oxidoreductases transposing C=C bonds. The systematic name of this enzyme class is 5-carboxymethyl-2-hydroxymuconate Delta2,Delta4-2-oxo,Delta3-isomerase. This enzyme participates in tyrosine metabolism and benzoate degradation via hydroxylation.

Structural studies

As of late 2007, 4 structures have been solved for this class of enzymes, with PDB accession codes 1GTT, 1I7O, 1WZO, and 2DFU.

References

• IUBMB entry for 5.3.3.10
• BRENDA references for 5.3.3.10 (Recommended.)
• PubMed references for 5.3.3.10
• PubMed Central references for 5.3.3.10
• Google Scholar references for 5.3.3.10
• Garrido-Pertierra A and Cooper RA (1981). "Identification and purification of distinct isomerase and decarboxylase enzymes involved in the 4-hydroxyphenylacetate pathway of Escherichia coli". Eur. J. Biochem. 117: 581–584. 

External links

The CAS registry number for this enzyme class is 79079-05-3.

• IUBMB entry for 5.3.3.10

• KEGG entry for 5.3.3.10

• BRENDA entry for 5.3.3.10

• NiceZyme view of 5.3.3.10

• EC2PDB: PDB structures for 5.3.3.10

• PRIAM entry for 5.3.3.10

• PUMA2 entry for 5.3.3.10

• IntEnz: Integrated Enzyme entry for 5.3.3.10

• MetaCyc entry for 5.3.3.10

• Atomic-resolution structures of enzymes belonging to this class

Gene Ontology (GO) codes

• EGO entry for GO code 0008704: 5-carboxymethyl-2-hydroxymuconate delta-isomerase

• AMIGO entry for GO code 0008704: 5-carboxymethyl-2-hydroxymuconate delta-isomerase