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5,6-dihydroxy-3-methyl-2-oxo-1,2,5,6-tetrahydroquinoline dehydrogenase

In enzymology, a 5,6-dihydroxy-3-methyl-2-oxo-1,2,5,6-tetrahydroquinoline dehydrogenase (EC 1.3.1.65) is an enzyme that catalyzes the chemical reaction

5,6-dihydroxy-3-methyl-2-oxo-1,2,5,6-tetrahydroquinoline + NAD⁺ 5,6-dihydroxy-3-methyl-2-oxo-1,2-dihydroquinoline + NADH + H⁺

Thus, the two substrates of this enzyme are 5,6-dihydroxy-3-methyl-2-oxo-1,2,5,6-tetrahydroquinoline and NAD⁺, whereas its 3 products are 5,6-dihydroxy-3-methyl-2-oxo-1,2-dihydroquinoline, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 5,6-dihydroxy-3-methyl-2-oxo-1,2,5,6-tetrahydroquinoline:NAD+ oxidoreductase.

References

• IUBMB entry for 1.3.1.65
• BRENDA references for 1.3.1.65 (Recommended.)
• PubMed references for 1.3.1.65
• PubMed Central references for 1.3.1.65
• Google Scholar references for 1.3.1.65
• Schach S, Schwarz G, Fetzner S, Lingens F (1993). "Microbial metabolism of quinoline and related compounds. XVII Degradation of 3-methylquinoline by Comamonas testosteroni 63". Biol. Chem. Hoppe. Seyler. 374: 175–81. PMID 8489738. 

External links

• IUBMB entry for 1.3.1.65

• KEGG entry for 1.3.1.65

• BRENDA entry for 1.3.1.65

• NiceZyme view of 1.3.1.65

• EC2PDB: PDB structures for 1.3.1.65

• PRIAM entry for 1.3.1.65

• PUMA2 entry for 1.3.1.65

• IntEnz: Integrated Enzyme entry for 1.3.1.65

• MetaCyc entry for 1.3.1.65

• Atomic-resolution structures of enzymes belonging to this class

Gene Ontology (GO) codes

• EGO entry for GO code 0018518: 5,6-dihydroxy-3-methyl-2-oxo-1,2,5,6-tetrahydroquinoline dehydrogenase

• AMIGO entry for GO code 0018518: 5,6-dihydroxy-3-methyl-2-oxo-1,2,5,6-tetrahydroquinoline dehydrogenase