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5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole

5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole, referred to as DRB, is a chemical compound that inhibits transcription elongation by RNA Polymerase II. Sensitivity to DRB is dependent on DSIF, NELF, and P-TEFb. DRB is a nucleoside analog and also inhibits some protein kinases.[1]

References

  1. ^ Yamaguchi, Y.; Takagi, T.; Wada, T.; Yano, K.; Furuya, A.; Sugimoto, S.; Hasegawa, J.; Handa, H. (1999). "NELF, a Multisubunit Complex Containing RD, Cooperates with DSIF to Repress RNA Polymerase II Elongation.". Cell 97: 41-51. PMID 10199401. 


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