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5'-acylphosphoadenosine hydrolase

In enzymology, a 5'-acylphosphoadenosine hydrolase (EC 3.6.1.20) is an enzyme that catalyzes the chemical reaction

5'-acylphosphoadenosine + H₂O AMP + a carboxylate

Thus, the two substrates of this enzyme are 5'-acylphosphoadenosine and H₂O, whereas its two products are AMP and carboxylate.

This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides in phosphorus-containing anhydrides. The systematic name of this enzyme class is 5'-acylphosphoadenosine acylhydrolase. This enzyme is also called 5-phosphoadenosine hydrolase. This enzyme participates in purine metabolism.

References

• IUBMB entry for 3.6.1.20
• BRENDA references for 3.6.1.20 (Recommended.)
• PubMed references for 3.6.1.20
• PubMed Central references for 3.6.1.20
• Google Scholar references for 3.6.1.20
• KELLERMAN GM (1959). "Isolation and characteristics of the enzyme acyl 5'-nucleotidase". Biochim. Biophys. Acta. 33: 101–5. doi:10.1016/0006-3002(59)90502-5. PMID 13651188. 

External links

The CAS registry number for this enzyme class is 37289-31-9.

• IUBMB entry for 3.6.1.20

• KEGG entry for 3.6.1.20

• BRENDA entry for 3.6.1.20

• NiceZyme view of 3.6.1.20

• EC2PDB: PDB structures for 3.6.1.20

• PRIAM entry for 3.6.1.20

• PUMA2 entry for 3.6.1.20

• IntEnz: Integrated Enzyme entry for 3.6.1.20

• MetaCyc entry for 3.6.1.20

• Atomic-resolution structures of enzymes belonging to this class

Gene Ontology (GO) codes

• EGO entry for GO code 0047586: 5'-acylphosphoadenosine hydrolase

• AMIGO entry for GO code 0047586: 5'-acylphosphoadenosine hydrolase