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4-trimethylammoniobutyraldehyde dehydrogenase

In enzymology, a 4-trimethylammoniobutyraldehyde dehydrogenase (EC 1.2.1.47) is an enzyme that catalyzes the chemical reaction

4-trimethylammoniobutanal + NAD⁺ + H₂O 4-trimethylammoniobutanoate + NADH + 2 H⁺

The 3 substrates of this enzyme are 4-trimethylammoniobutanal, NAD⁺, and H₂O, whereas its 3 products are 4-trimethylammoniobutanoate, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 4-trimethylammoniobutanal:NAD+ 1-oxidoreductase. Other names in common use include 4-trimethylaminobutyraldehyde dehydrogenase, and 4-N-trimethylaminobutyraldehyde dehydrogenase. This enzyme participates in lysine degradation.

References

• IUBMB entry for 1.2.1.47
• BRENDA references for 1.2.1.47 (Recommended.)
• PubMed references for 1.2.1.47
• PubMed Central references for 1.2.1.47
• Google Scholar references for 1.2.1.47
• Rebouche CJ, Engel AG (1980). "Tissue distribution of carnitine biosynthetic enzymes in man". Biochim. Biophys. Acta. 630: 22–9. PMID 6770910. 

External links

The CAS registry number for this enzyme class is 73361-01-0.

• IUBMB entry for 1.2.1.47

• KEGG entry for 1.2.1.47

• BRENDA entry for 1.2.1.47

• NiceZyme view of 1.2.1.47

• EC2PDB: PDB structures for 1.2.1.47

• PRIAM entry for 1.2.1.47

• PUMA2 entry for 1.2.1.47

• IntEnz: Integrated Enzyme entry for 1.2.1.47

• MetaCyc entry for 1.2.1.47

• Atomic-resolution structures of enzymes belonging to this class

Gene Ontology (GO) codes

• EGO entry for GO code 0047105: 4-trimethylammoniobutyraldehyde dehydrogenase

• AMIGO entry for GO code 0047105: 4-trimethylammoniobutyraldehyde dehydrogenase