4-alpha-glucanotransferase

In enzymology, a 4-alpha-glucanotransferase (EC 2.4.1.25) is an enzyme that catalyzes a chemical reaction that transfers a segment of a 1,4-alpha-D-glucan to a new position in an acceptor carbohydrate, which may be glucose or a 1,4-alpha-D-glucan.

This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. The systematic name of this enzyme class is 1,4-alpha-D-glucan:1,4-alpha-D-glucan 4-alpha-D-glycosyltransferase. Other names in common use include disproportionating enzyme, dextrin glycosyltransferase, D-enzyme, debranching enzyme maltodextrin glycosyltransferase, amylomaltase, and dextrin transglycosylase. This enzyme participates in starch and sucrose metabolism.

1 Structural studies
2 References
3 External links
- 3.1 Gene Ontology (GO) codes

Structural studies

As of late 2007, 14 structures have been solved for this class of enzymes, with PDB accession codes 1CWY, 1ESW, 1FP8, 1FP9, 1K1W, 1K1X, 1K1Y, 1LWH, 1LWJ, 1TZ7, 1X1N, 2OWC, 2OWW, and 2OWX.

References

IUBMB entry for 2.4.1.25
BRENDA references for 2.4.1.25 (Recommended.)
PubMed references for 2.4.1.25
PubMed Central references for 2.4.1.25
Google Scholar references for 2.4.1.25
Hehre EJ (1951). "Enzymic synthesis of polysaccharides: a biological type of polymerization". Adv. Enzymol. Relat. Subj. Biochem. 11: 297–337.
Lukomskaya IS (1959). "Synthesis of oligosaccharides with alpha-1,6-bonds by enzyme preparations from liver and muscle". Dokl. Akad. Nauk S.S.S.R. 129: 1172–1175.
Pazur JH, Okada S (1968). "The isolation and mode of action of a bacterial glucanosyltransferase". J. Biol. Chem. 243: 4732–8. PMID 4972097.
Walker GJ and Whelan WJ (1959). "Synthesis of amylose by potato D-enzyme". Nature 183: 46.
Whelan WH (1971). "Enzymic explorations of the structures of starch and glycogen". Biochem. J. 122: 609–622.