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4-acetamidobutyryl-CoA deacetylase

In enzymology, a 4-acetamidobutyryl-CoA deacetylase (EC 3.5.1.51) is an enzyme that catalyzes the chemical reaction

4-acetamidobutanoyl-CoA + H₂O acetate + 4-aminobutanoyl-CoA

Thus, the two substrates of this enzyme are 4-acetamidobutanoyl-CoA and H₂O, whereas its two products are acetate and 4-aminobutanoyl-CoA.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in linear amides. The systematic name of this enzyme class is 4-acetamidobutanoyl-CoA amidohydrolase. Other names in common use include aminobutyryl-CoA thiolesterase, and deacetylase-thiolesterase.

References

• IUBMB entry for 3.5.1.51
• BRENDA references for 3.5.1.51 (Recommended.)
• PubMed references for 3.5.1.51
• PubMed Central references for 3.5.1.51
• Google Scholar references for 3.5.1.51
• Ohsugi M, Kahn J, Hensley C, Chew S, Barker HA (1981). "Metabolism of L-beta-lysine by a Pseudomonas. Purification and properties of a deacetylase-thiolesterase utilizing 4-acetamidobutyryl CoA and related compounds". J. Biol. Chem. 256: 7642–51. PMID 6788773. 

External links

• IUBMB entry for 3.5.1.51

• KEGG entry for 3.5.1.51

• BRENDA entry for 3.5.1.51

• NiceZyme view of 3.5.1.51

• EC2PDB: PDB structures for 3.5.1.51

• PRIAM entry for 3.5.1.51

• PUMA2 entry for 3.5.1.51

• IntEnz: Integrated Enzyme entry for 3.5.1.51

• MetaCyc entry for 3.5.1.51

• Atomic-resolution structures of enzymes belonging to this class

Gene Ontology (GO) codes

• EGO entry for GO code 0047574: 4-acetamidobutyryl-CoA deacetylase

• AMIGO entry for GO code 0047574: 4-acetamidobutyryl-CoA deacetylase