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4-Deoxypyridoxine

4-Deoxypyridoxine
Identifiers
CAS number [148-51-6]
PubChem 6094
SMILES CC1=C(C(=NC=C1CO)C)O
Properties
Molecular formula C8H11NO2
Molar mass 153.178 g/mol
Except where noted otherwise, data are given for
materials in their standard state
(at 25 °C, 100 kPa)
Infobox disclaimer and references

4-Deoxypyridoxine is a vitamin B6 antagonist.[1] It may be toxic to developing embryos since it can have negative effects on collagen and elastin during development.[2] The presence of this compound can produce vitamin B6 deficiency, which suppresses the immune system.[3] This immunosuppression can be beneficial in animal models of Trichinella spiralis infections.[4]

References

  1. ^ Coburn SP, Mahuren JD, Schaltenbrand WE, Wostmann BS, Madsen D (1981). "Effects of vitamin B-6 deficiency and 4'- deoxypyridoxine on pyridoxal phosphate concentrations, pyridoxine kinase and other aspects of metabolism in the rat". J. Nutr. 111 (2): 391–8. PMID 6257871. 
  2. ^ Bird TA, Levene CI (1983). "The effect of a vitamin B-6 antagonist, 4-deoxypyridoxine, on the cross-linking of collagen in the developing chick embryo". Biochem. J. 210 (3): 633–8. PMID 6135414. 
  3. ^ Trakatellis A, Dimitriadou A, Exindari M, et al (1992). "Effect of pyridoxine deficiency on immunological phenomena". Postgrad Med J 68 Suppl 1: S70–7. PMID 1409221. 
  4. ^ Frydas S, Papaioanou N, Vlemmas I, et al (1999). "Vitamin B6-deficient diet plus 4-deoxypyridoxine (4-DPD) reduces the inflammatory response induced by T. spiralis in diaphragm, masseter and heart muscle tissue of mice". Mol. Cell. Biochem. 197 (1-2): 79–85. PMID 10485327. 
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