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4-(2-carboxyphenyl)-2-oxobut-3-enoate aldolase

In enzymology, a 4-(2-carboxyphenyl)-2-oxobut-3-enoate aldolase (EC 4.1.2.34) is an enzyme that catalyzes the chemical reaction

(3Z)-4-(2-carboxyphenyl)-2-oxobut-3-enoate + H₂O 2-formylbenzoate + pyruvate

Thus, the two substrates of this enzyme are (3Z)-4-(2-carboxyphenyl)-2-oxobut-3-enoate and H₂O, whereas its two products are 2-formylbenzoate and pyruvate.

This enzyme belongs to the family of lyases, specifically the aldehyde-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is (3Z)-4-(2-carboxyphenyl)-2-oxobut-3-enoate 2-formylbenzoate-lyase (pyruvate-forming). Other names in common use include 2'-carboxybenzalpyruvate aldolase, (3E)-4-(2-carboxyphenyl)-2-oxobut-3-enoate, 2-carboxybenzaldehyde-lyase, and (3Z)-4-(2-carboxyphenyl)-2-oxobut-3-enoate 2-formylbenzoate-lyase. This enzyme participates in naphthalene and anthracene degradation.

References

• IUBMB entry for 4.1.2.34
• BRENDA references for 4.1.2.34 (Recommended.)
• PubMed references for 4.1.2.34
• PubMed Central references for 4.1.2.34
• Google Scholar references for 4.1.2.34
• Barnsley EA (1983). "Phthalate pathway of phenanthrene metabolism: formation of 2'-carboxybenzalpyruvate". J. Bacteriol. 154: 113–7. PMID 6833175. 

External links

The CAS registry number for this enzyme class is 86611-90-7.

• IUBMB entry for 4.1.2.34

• KEGG entry for 4.1.2.34

• BRENDA entry for 4.1.2.34

• NiceZyme view of 4.1.2.34

• EC2PDB: PDB structures for 4.1.2.34

• PRIAM entry for 4.1.2.34

• PUMA2 entry for 4.1.2.34

• IntEnz: Integrated Enzyme entry for 4.1.2.34

• MetaCyc entry for 4.1.2.34

• Atomic-resolution structures of enzymes belonging to this class

Gene Ontology (GO) codes

• EGO entry for GO code 0018803: 4-(2-carboxyphenyl)-2-oxobut-3-enoate aldolase

• AMIGO entry for GO code 0018803: 4-(2-carboxyphenyl)-2-oxobut-3-enoate aldolase