3-oxoadipyl-CoA thiolase

In enzymology, a 3-oxoadipyl-CoA thiolase (EC 2.3.1.174) is an enzyme that catalyzes the chemical reaction

succinyl-CoA + acetyl-CoA CoA + 3-oxoadipyl-CoA

Thus, the two substrates of this enzyme are succinyl-CoA and acetyl-CoA, whereas its two products are CoA and 3-oxoadipyl-CoA.

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is succinyl-CoA:acetyl-CoA C-succinyltransferase. This enzyme participates in benzoate degradation via hydroxylation.

References

IUBMB entry for 2.3.1.174
BRENDA references for 2.3.1.174 (Recommended.)
PubMed references for 2.3.1.174
PubMed Central references for 2.3.1.174
Google Scholar references for 2.3.1.174
Kaschabek SR, Kuhn B, Muller D, Schmidt E, Reineke W (2002). "Degradation of aromatics and chloroaromatics by Pseudomonas sp strain B13: purification and characterization of 3-oxoadipate:succinyl-coenzyme A (CoA) transferase and 3-oxoadipyl-CoA thiolase". J. Bacteriol. 184: 207–15. PMID 11741862.
Gobel M, Kassel-Cati K, Schmidt E, Reineke W (2002). "Degradation of aromatics and chloroaromatics by Pseudomonas sp strain B13: cloning, characterization, and analysis of sequences encoding 3-oxoadipate:succinyl-coenzyme A (CoA) transferase and 3-oxoadipyl-CoA thiolase". J. Bacteriol. 184: 216–23. PMID 11741863.