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3-oxoacyl-(acyl-carrier-protein) reductase

In enzymology, a 3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100) is an enzyme that catalyzes the chemical reaction

(3R)-3-hydroxyacyl-[acyl-carrier-protein] + NADP⁺ 3-oxoacyl-[acyl-carrier-protein] + NADPH + H⁺

Thus, the two substrates of this enzyme are [[(3R)-3-hydroxyacyl-[acyl-carrier-protein]]] and NADP⁺, whereas its 3 products are [[3-oxoacyl-[acyl-carrier-protein]]], NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (3R)-3-hydroxyacyl-[acyl-carrier-protein]:NADP+ oxidoreductase. Other names in common use include beta-ketoacyl-[acyl-carrier protein](ACP) reductase, beta-ketoacyl acyl carrier protein (ACP) reductase, beta-ketoacyl reductase, beta-ketoacyl thioester reductase, beta-ketoacyl-ACP reductase, beta-ketoacyl-acyl carrier protein reductase, 3-ketoacyl acyl carrier protein reductase, NADPH-specific 3-oxoacyl-[acylcarrier protein]reductase, and 3-oxoacyl-[ACP]reductase. This enzyme participates in fatty acid biosynthesis and polyunsaturated fatty acid biosynthesis.

Structural studies

As of late 2007, 21 structures have been solved for this class of enzymes, with PDB accession codes 1I01, 1O5I, 1Q7B, 1Q7C, 1ULS, 1UZL, 1UZM, 1UZN, 2A4K, 2B4Q, 2C07, 2FR0, 2FR1, 2NM0, 2NTN, 2P68, 2PFF, 2PH3, 2PNF, 2UVD, and 2Z5L.

References

• IUBMB entry for 1.1.1.100
• BRENDA references for 1.1.1.100 (Recommended.)
• PubMed references for 1.1.1.100
• PubMed Central references for 1.1.1.100
• Google Scholar references for 1.1.1.100
• Prescott DJ, Vagelos PR (1972). "Acyl carrier protein". Adv. Enzymol. Relat. Areas. Mol. Biol. 36: 269–311. PMID 4561013. 
• Shimakata T, Stumpf PK (1982). "Purification and characterizations of beta-Ketoacyl-[acyl-carrier-protein] reductase, beta-hydroxyacyl-[acylcarrier-protein] dehydrase, and enoyl-[acyl-carrier-protein] reductase from Spinacia oleracea leaves". Arch. Biochem. Biophys. 218: 77–91. PMID 6756317. 
• Toomey RE, Wakil SJ (1966). "Studies on the mechanism of fatty acid synthesis. XV. Preparation and general properties of beta-ketoacyl acyl carrier protein reductase from Escherichia coli". Biochim. Biophys. Acta. 116: 189–97. PMID 4381013. 

External links

The CAS registry number for this enzyme class is 37250-34-3.

• IUBMB entry for 1.1.1.100

• KEGG entry for 1.1.1.100

• BRENDA entry for 1.1.1.100

• NiceZyme view of 1.1.1.100

• EC2PDB: PDB structures for 1.1.1.100

• PRIAM entry for 1.1.1.100

• PUMA2 entry for 1.1.1.100

• IntEnz: Integrated Enzyme entry for 1.1.1.100

• MetaCyc entry for 1.1.1.100

• Atomic-resolution structures of enzymes belonging to this class

Gene Ontology (GO) codes

• EGO entry for GO code 0004316: 3-oxoacyl-[acyl-carrier-protein reductase]

• AMIGO entry for GO code 0004316: 3-oxoacyl-[acyl-carrier-protein reductase]