3-oxoacid CoA-transferase

In enzymology, a 3-oxoacid CoA-transferase (EC 2.8.3.5) is an enzyme that catalyzes the chemical reaction

succinyl-CoA + a 3-oxo acid succinate + a 3-oxoacyl-CoA

Thus, the two substrates of this enzyme are succinyl-CoA and 3-oxo acid, whereas its two products are succinate and 3-oxoacyl-CoA.

This enzyme belongs to the family of transferases, specifically the CoA-transferases. The systematic name of this enzyme class is succinyl-CoA:3-oxo-acid CoA-transferase. Other names in common use include 3-oxoacid coenzyme A-transferase, 3-ketoacid CoA-transferase, 3-ketoacid coenzyme A transferase, 3-oxo-CoA transferase, 3-oxoacid CoA dehydrogenase, acetoacetate succinyl-CoA transferase, acetoacetyl coenzyme A-succinic thiophorase, succinyl coenzyme A-acetoacetyl coenzyme A-transferase, and succinyl-CoA transferase. This enzyme participates in 3 metabolic pathways: synthesis and degradation of ketone bodies, valine, leucine and isoleucine degradation, and butanoate metabolism.

1 Structural studies
2 References
3 External links
- 3.1 Gene Ontology (GO) codes

Structural studies

As of late 2007, 7 structures have been solved for this class of enzymes, with PDB accession codes 1M3E, 1O9L, 1OOY, 1OOZ, 1OPE, 2NRB, and 2NRC.

References

IUBMB entry for 2.8.3.5
BRENDA references for 2.8.3.5 (Recommended.)
PubMed references for 2.8.3.5
PubMed Central references for 2.8.3.5
Google Scholar references for 2.8.3.5
Hersh LB and Jencks WP (1967). "Coenzyme A transferase. Kinetics and exchange reactions". J. Biol. Chem. 242: 3468–3480.
LYNEN F, OCHOA S (1953). "Enzymes of fatty acid metabolism". Biochim. Biophys. Acta. 12: 299–314. doi:10.1016/0006-3002(53)90149-8. PMID 13115439.
Menon GKK and Stern JR (1960). "Enzymic synthesis and metabolism of malonyl coenzyme A and glutaryl coenzyme A". J. Biol. Chem. 235: 3393–3398.
Stern JR, Coon MJ, del Campillo A and Schneider MC (1956). "Enzymes of fatty acid metabolism. IV. Preparation and properties of coenzyme A transferase". J. Biol. Chem. 221: 15–31.