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3-oxo-5beta-steroid 4-dehydrogenase

In enzymology, a 3-oxo-5beta-steroid 4-dehydrogenase (EC 1.3.99.6) is an enzyme that catalyzes the chemical reaction

a 3-oxo-5beta-steroid + acceptor a 3-oxo-Delta₄-steroid + reduced acceptor

Thus, the two substrates of this enzyme are 3-oxo-5beta-steroid and acceptor, whereas its two products are 3-oxo-Delta4-steroid and reduced acceptor.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with other acceptors. The systematic name of this enzyme class is 3-oxo-5beta-steroid:acceptor Delta4-oxidoreductase. This enzyme is also called 3-oxo-5beta-steroid:(acceptor) Delta4-oxidoreductase. This enzyme participates in 3 metabolic pathways: bile acid biosynthesis, c21-steroid hormone metabolism, and androgen and estrogen metabolism.

References

• IUBMB entry for 1.3.99.6
• BRENDA references for 1.3.99.6 (Recommended.)
• PubMed references for 1.3.99.6
• PubMed Central references for 1.3.99.6
• Google Scholar references for 1.3.99.6
• Davidson SJ, Talalay P (1966). "Purification and mechanism of action of a steroid delta-4-5-beta-dehydrogenase". J. Biol. Chem. 241: 906–15. PMID 5907467. 

External links

The CAS registry number for this enzyme class is 9067-97-4.

• IUBMB entry for 1.3.99.6

• KEGG entry for 1.3.99.6

• BRENDA entry for 1.3.99.6

• NiceZyme view of 1.3.99.6

• EC2PDB: PDB structures for 1.3.99.6

• PRIAM entry for 1.3.99.6

• PUMA2 entry for 1.3.99.6

• IntEnz: Integrated Enzyme entry for 1.3.99.6

• MetaCyc entry for 1.3.99.6

• Atomic-resolution structures of enzymes belonging to this class

Gene Ontology (GO) codes

• EGO entry for GO code 0047568: 3-oxo-5-beta-steroid 4-dehydrogenase

• AMIGO entry for GO code 0047568: 3-oxo-5-beta-steroid 4-dehydrogenase