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3-cyanoalanine hydratase

In enzymology, a 3-cyanoalanine hydratase (EC 4.2.1.65) is an enzyme that catalyzes the chemical reaction

L-asparagine 3-cyanoalanine + H₂O

Hence, this enzyme has one substrate, L-asparagine, and two products, 3-cyanoalanine and H₂O.

This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is L-asparagine hydro-lyase (3-cyanoalanine-forming). Other names in common use include beta-cyanoalanine hydrolase, beta-cyanoalanine hydratase, beta-CNAla hydrolase, beta-CNA nitrilase, and L-asparagine hydro-lyase. This enzyme participates in cyanoamino acid metabolism.

References

• IUBMB entry for 4.2.1.65
• BRENDA references for 4.2.1.65 (Recommended.)
• PubMed references for 4.2.1.65
• PubMed Central references for 4.2.1.65
• Google Scholar references for 4.2.1.65
• Castric PA, Farnden KJ, Conn EE (1972). "Cyanide metabolism in higher plants. V. The formation of asparagine from -cyanoalanine". Arch. Biochem. Biophys. 152: 62–9. doi:10.1016/0003-9861(72)90193-2. PMID 4627358. 

External links

The CAS registry number for this enzyme class is 37259-64-6.

• IUBMB entry for 4.2.1.65

• KEGG entry for 4.2.1.65

• BRENDA entry for 4.2.1.65

• NiceZyme view of 4.2.1.65

• EC2PDB: PDB structures for 4.2.1.65

• PRIAM entry for 4.2.1.65

• PUMA2 entry for 4.2.1.65

• IntEnz: Integrated Enzyme entry for 4.2.1.65

• MetaCyc entry for 4.2.1.65

• Atomic-resolution structures of enzymes belonging to this class

Gene Ontology (GO) codes

• EGO entry for GO code 0047558: 3-cyanoalanine hydratase

• AMIGO entry for GO code 0047558: 3-cyanoalanine hydratase