3-chloro-D-alanine dehydrochlorinase

In enzymology, a 3-chloro-D-alanine dehydrochlorinase (EC 4.5.1.2) is an enzyme that catalyzes the chemical reaction

3-chloro-D-alanine + H₂O pyruvate + chloride + NH₃

Thus, the two substrates of this enzyme are 3-chloro-D-alanine and H₂O, whereas its 3 products are pyruvate, chloride, and NH₃.

This enzyme belongs to the family of lyases, specifically the class of carbon-halide lyases. The systematic name of this enzyme class is 3-chloro-D-alanine chloride-lyase (deaminating; pyruvate-forming). Other names in common use include beta-chloro-D-alanine dehydrochlorinase, and 3-chloro-D-alanine chloride-lyase (deaminating). It employs one cofactor, pyridoxal phosphate.

References

IUBMB entry for 4.5.1.2
BRENDA references for 4.5.1.2 (Recommended.)
PubMed references for 4.5.1.2
PubMed Central references for 4.5.1.2
Google Scholar references for 4.5.1.2
Nagasawa T, Ishii T, Yamada H (1988). "Physiological comparison of D-cysteine desulfhydrase of Escherichia coli with 3-chloro-D-alanine dehydrochlorinase of Pseudomonas putida CR 1-1". Arch. Microbiol. 149: 413–6. doi:10.1007/BF00425580. PMID 3132906.
Yamada H, Nagasawa T, Ohkishi H, Kawakami B, Tani Y (1981). "Synthesis of D-cysteine from 3-chloro-D-alanine and hydrogen sulfide by 3-chloro-D-alanine hydrogen chloride-lyase (deaminating) of Pseudomonas putida". Biochem. Biophys. Res. Commun. 100: 1104–10. doi:10.1016/0006-291X(81)91937-9. PMID 6791643.