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3-carboxyethylcatechol 2,3-dioxygenase

In enzymology, a 3-carboxyethylcatechol 2,3-dioxygenase (EC 1.13.11.16) is an enzyme that catalyzes the chemical reaction

3-(2,3-dihydroxyphenyl)propanoate + O₂ 2-hydroxy-6-oxonona-2,4-diene-1,9-dioate

Thus, the two substrates of this enzyme are 3-(2,3-dihydroxyphenyl)propanoate and O₂, whereas its product is 2-hydroxy-6-oxonona-2,4-diene-1,9-dioate.

This enzyme belongs to the family of oxidoreductases, specifically those acting on single donors with O₂ as oxidant and incorporation of two atoms of oxygen into the substrate (oxygenases). The oxygen incorporated need not be derived from O₂. The systematic name of this enzyme class is 3-(2,3-dihydroxyphenyl)propanoate:oxygen 1,2-oxidoreductase (decyclizing). Other names in common use include 2,3-dihydroxy-beta-phenylpropionic dioxygenase, 2,3-dihydroxy-beta-phenylpropionate oxygenase, and 3-(2,3-dihydroxyphenyl)propanoate:oxygen 1,2-oxidoreductase. This enzyme participates in phenylalanine metabolism. It employs one cofactor, iron.

References

• IUBMB entry for 1.13.11.16
• BRENDA references for 1.13.11.16 (Recommended.)
• PubMed references for 1.13.11.16
• PubMed Central references for 1.13.11.16
• Google Scholar references for 1.13.11.16
• Dagley S, Chapman PJ, Gibson DT (1965). "The metabolism of beta-phenylpropionic acid by an Achromobacter". Biochem. J. 97: 643–50. PMID 5881653. 

External links

The CAS registry number for this enzyme class is 105503-63-7.

• IUBMB entry for 1.13.11.16

• KEGG entry for 1.13.11.16

• BRENDA entry for 1.13.11.16

• NiceZyme view of 1.13.11.16

• EC2PDB: PDB structures for 1.13.11.16

• PRIAM entry for 1.13.11.16

• PUMA2 entry for 1.13.11.16

• IntEnz: Integrated Enzyme entry for 1.13.11.16

• MetaCyc entry for 1.13.11.16

• Atomic-resolution structures of enzymes belonging to this class

Gene Ontology (GO) codes

• EGO entry for GO code 0047070: 3-carboxyethylcatechol 2,3-dioxygenase

• AMIGO entry for GO code 0047070: 3-carboxyethylcatechol 2,3-dioxygenase