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3-aminobutyryl-CoA ammonia-lyase

In enzymology, a 3-aminobutyryl-CoA ammonia-lyase (EC 4.3.1.14) is an enzyme that catalyzes the chemical reaction

L-3-aminobutyryl-CoA crotonoyl-CoA + NH₃

Hence, this enzyme has one substrate, L-3-aminobutyryl-CoA, and two products, crotonoyl-CoA and NH₃.

This enzyme belongs to the family of lyases, specifically ammonia lyases, which cleave carbon-nitrogen bonds. The systematic name of this enzyme class is L-3-aminobutyryl-CoA ammonia-lyase (crotonoyl-CoA-forming). Other names in common use include L-3-aminobutyryl-CoA deaminase, and L-3-aminobutyryl-CoA ammonia-lyase.

References

• IUBMB entry for 4.3.1.14
• BRENDA references for 4.3.1.14 (Recommended.)
• PubMed references for 4.3.1.14
• PubMed Central references for 4.3.1.14
• Google Scholar references for 4.3.1.14
• Jeng I, Barker HA (1974). "Purification and properties of l-3-aminobutyryl coenzyme A deaminase from a lysine-fermenting Clostridium". J. Biol. Chem. 249: 6578–84. PMID 4420467. 
• Barker HA, Kahn JM, Chew S (1980). "Enzymes involved in 3,5-diaminohexanoate degradation by Brevibacterium sp". J. Bacteriol. 143: 1165–70. PMID 7410315. 

External links

The CAS registry number for this enzyme class is 55467-41-9.

• IUBMB entry for 4.3.1.14

• KEGG entry for 4.3.1.14

• BRENDA entry for 4.3.1.14

• NiceZyme view of 4.3.1.14

• EC2PDB: PDB structures for 4.3.1.14

• PRIAM entry for 4.3.1.14

• PUMA2 entry for 4.3.1.14

• IntEnz: Integrated Enzyme entry for 4.3.1.14

• MetaCyc entry for 4.3.1.14

• Atomic-resolution structures of enzymes belonging to this class

Gene Ontology (GO) codes

• EGO entry for GO code 0047459: 3-aminobutyryl-CoA ammonia-lyase

• AMIGO entry for GO code 0047459: 3-aminobutyryl-CoA ammonia-lyase