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3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione 4,5-dioxygenase

In enzymology, a 3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione 4,5-dioxygenase (EC 1.13.11.25) is an enzyme that catalyzes the chemical reaction

3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + O₂ 3-hydroxy-5,9,17-trioxo-4,5:9,10-disecoandrosta-1(10),2-dien-4-oate

Thus, the two substrates of this enzyme are 3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione and O₂, whereas its product is 3-hydroxy-5,9,17-trioxo-4,5:9,10-disecoandrosta-1(10),2-dien-4-oate.

This enzyme belongs to the family of oxidoreductases, specifically those acting on single donors with O₂ as oxidant and incorporation of two atoms of oxygen into the substrate (oxygenases). The oxygen incorporated need not be derived from O₂. The systematic name of this enzyme class is 3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione:oxygen 4,5-oxidoreductase (decyclizing). Other names in common use include steroid 4,5-dioxygenase, and 3-alkylcatechol 2,3-dioxygenase. It employs one cofactor, iron.

References

• IUBMB entry for 1.13.11.25
• BRENDA references for 1.13.11.25 (Recommended.)
• PubMed references for 1.13.11.25
• PubMed Central references for 1.13.11.25
• Google Scholar references for 1.13.11.25
• Gibson DT, Wang KC, Sih CJ, Whitlock H Jr (1966). "Mechanisms of steroid oxidation by microorganisms. IX. On the mechanism of ring A cleavage in the degradation of 9,10-seco steroids by microorganisms". J. Biol. Chem. 241: 551–9. PMID 5908121. 

External links

The CAS registry number for this enzyme class is 37256-63-6.

• IUBMB entry for 1.13.11.25

• KEGG entry for 1.13.11.25

• BRENDA entry for 1.13.11.25

• NiceZyme view of 1.13.11.25

• EC2PDB: PDB structures for 1.13.11.25

• PRIAM entry for 1.13.11.25

• PUMA2 entry for 1.13.11.25

• IntEnz: Integrated Enzyme entry for 1.13.11.25

• MetaCyc entry for 1.13.11.25

• Atomic-resolution structures of enzymes belonging to this class

Gene Ontology (GO) codes

• EGO entry for GO code 0047071: 3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione 4,5-dioxygenase

• AMIGO entry for GO code 0047071: 3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione 4,5-dioxygenase