Home › Multilingual Archive Index › 2-dehydro-3-deoxygluconokinase

2-dehydro-3-deoxygluconokinase

In enzymology, a 2-dehydro-3-deoxygluconokinase (EC 2.7.1.45) is an enzyme that catalyzes the chemical reaction

ATP + 2-dehydro-3-deoxy-D-gluconate ADP + 6-phospho-2-dehydro-3-deoxy-D-gluconate

Thus, the two substrates of this enzyme are ATP and 2-dehydro-3-deoxy-D-gluconate, whereas its two products are ADP and 6-phospho-2-dehydro-3-deoxy-D-gluconate.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor. The systematic name of this enzyme class is ATP:2-dehydro-3-deoxy-D-gluconate 6-phosphotransferase. Other names in common use include 2-keto-3-deoxygluconokinase, 2-keto-3-deoxy-D-gluconic acid kinase, 2-keto-3-deoxygluconokinase (phosphorylating), 2-keto-3-deoxygluconate kinase, and ketodeoxygluconokinase. This enzyme participates in pentose phosphate pathway and pentose and glucuronate interconversions.

Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 1WYE.

References

• IUBMB entry for 2.7.1.45
• BRENDA references for 2.7.1.45 (Recommended.)
• PubMed references for 2.7.1.45
• PubMed Central references for 2.7.1.45
• Google Scholar references for 2.7.1.45
• CYNKIN MA, ASHWELL G (1960). "Uronic acid metabolism in bacteria. IV. Purification and properties of 2-keto-3-deoxy-D-gluconokinase in Escherichia coli". J. Biol. Chem. 235: 1576–9. PMID 13813474. 

External links

The CAS registry number for this enzyme class is 9026-54-4.

• IUBMB entry for 2.7.1.45

• KEGG entry for 2.7.1.45

• BRENDA entry for 2.7.1.45

• NiceZyme view of 2.7.1.45

• EC2PDB: PDB structures for 2.7.1.45

• PRIAM entry for 2.7.1.45

• PUMA2 entry for 2.7.1.45

• IntEnz: Integrated Enzyme entry for 2.7.1.45

• MetaCyc entry for 2.7.1.45

• Atomic-resolution structures of enzymes belonging to this class

Gene Ontology (GO) codes

• EGO entry for GO code 0008673: 2-dehydro-3-deoxygluconokinase

• AMIGO entry for GO code 0008673: 2-dehydro-3-deoxygluconokinase