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2-dehydro-3-deoxy-L-arabinonate dehydratase

In enzymology, a 2-dehydro-3-deoxy-L-arabinonate dehydratase (EC 4.2.1.43) is an enzyme that catalyzes the chemical reaction

2-dehydro-3-deoxy-L-arabinonate 2,5-dioxopentanoate + H₂O

Hence, this enzyme has one substrate, 2-dehydro-3-deoxy-L-arabinonate, and two products, 2,5-dioxopentanoate and H₂O.

This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is 2-dehydro-3-deoxy-L-arabinonate hydro-lyase (2,5-dioxopentanoate-forming). Other names in common use include 2-keto-3-deoxy-L-arabinonate dehydratase, and 2-dehydro-3-deoxy-L-arabinonate hydro-lyase. This enzyme participates in ascorbate and aldarate metabolism.

References

• IUBMB entry for 4.2.1.43
• BRENDA references for 4.2.1.43 (Recommended.)
• PubMed references for 4.2.1.43
• PubMed Central references for 4.2.1.43
• Google Scholar references for 4.2.1.43
• Stoolmiller AC, Abeles RH (1966). "Formation of alpha-ketoglutaric semialdehyde from L-2-keto-3-deoxyarabonic acid and isolation of L-2-keto-3-deoxyarabonate dehydratase from Pseudomonas saccharophila". J. Biol. Chem. 241: 5764–71. PMID 5954356. 

External links

The CAS registry number for this enzyme class is 37263-10-8.

• IUBMB entry for 4.2.1.43

• KEGG entry for 4.2.1.43

• BRENDA entry for 4.2.1.43

• NiceZyme view of 4.2.1.43

• EC2PDB: PDB structures for 4.2.1.43

• PRIAM entry for 4.2.1.43

• PUMA2 entry for 4.2.1.43

• IntEnz: Integrated Enzyme entry for 4.2.1.43

• MetaCyc entry for 4.2.1.43

• Atomic-resolution structures of enzymes belonging to this class

Gene Ontology (GO) codes

• EGO entry for GO code 0047449: 2-dehydro-3-deoxy-L-arabinonate dehydratase

• AMIGO entry for GO code 0047449: 2-dehydro-3-deoxy-L-arabinonate dehydratase