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2-dehydro-3-deoxy-D-gluconate 6-dehydrogenase

In enzymology, a 2-dehydro-3-deoxy-D-gluconate 6-dehydrogenase (EC 1.1.1.126) is an enzyme that catalyzes the chemical reaction

2-dehydro-3-deoxy-D-gluconate + NADP⁺ (4S,5S)-4,5-dihydroxy-2,6-dioxohexanoate + NADPH + H⁺

Thus, the two substrates of this enzyme are 2-dehydro-3-deoxy-D-gluconate and NADP⁺, whereas its 3 products are (4S,5S)-4,5-dihydroxy-2,6-dioxohexanoate, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 2-dehydro-3-deoxy-D-gluconate:NADP+ 6-oxidoreductase. Other names in common use include 2-keto-3-deoxy-D-gluconate dehydrogenase, and 2-keto-3-deoxygluconate dehydrogenase.

References

• IUBMB entry for 1.1.1.126
• BRENDA references for 1.1.1.126 (Recommended.)
• PubMed references for 1.1.1.126
• PubMed Central references for 1.1.1.126
• Google Scholar references for 1.1.1.126
• Preiss J and Ashwell G (1962). "Alginic acid metabolism in bacteria. II. The enzymatic reduction of 4-deoxy-L-erythro-5-hexoseulose uronic acid to 2-keto-3-deoxy-D-gluconic acid". J. Biol. Chem. 237: 317–321. 

External links

The CAS registry number for this enzyme class is 37250-55-8.

• IUBMB entry for 1.1.1.126

• KEGG entry for 1.1.1.126

• BRENDA entry for 1.1.1.126

• NiceZyme view of 1.1.1.126

• EC2PDB: PDB structures for 1.1.1.126

• PRIAM entry for 1.1.1.126

• PUMA2 entry for 1.1.1.126

• IntEnz: Integrated Enzyme entry for 1.1.1.126

• MetaCyc entry for 1.1.1.126

• Atomic-resolution structures of enzymes belonging to this class

Gene Ontology (GO) codes

• EGO entry for GO code 0047000: 2-dehydro-3-deoxy-D-gluconate 6-dehydrogenase

• AMIGO entry for GO code 0047000: 2-dehydro-3-deoxy-D-gluconate 6-dehydrogenase