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2-dehydro-3-deoxy-6-phosphogalactonate aldolase

In enzymology, a 2-dehydro-3-deoxy-6-phosphogalactonate aldolase (EC 4.1.2.21) is an enzyme that catalyzes the chemical reaction

2-dehydro-3-deoxy-D-galactonate 6-phosphate pyruvate + D-glyceraldehyde 3-phosphate

Hence, this enzyme has one substrate, 2-dehydro-3-deoxy-D-galactonate 6-phosphate, and two products, pyruvate and D-glyceraldehyde 3-phosphate.

This enzyme belongs to the family of lyases, specifically the aldehyde-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is 2-dehydro-3-deoxy-D-galactonate-6-phosphate D-glyceraldehyde-3-phosphate-lyase (pyruvate-forming). Other names in common use include 6-phospho-2-keto-3-deoxygalactonate aldolase, phospho-2-keto-3-deoxygalactonate aldolase, 2-keto-3-deoxy-6-phosphogalactonic aldolase, phospho-2-keto-3-deoxygalactonic aldolase, 2-keto-3-deoxy-6-phosphogalactonic acid aldolase, (KDPGal)aldolase, 2-dehydro-3-deoxy-D-galactonate-6-phosphate, and D-glyceraldehyde-3-phosphate-lyase. This enzyme participates in galactose metabolism.

Structural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 2V81 and 2V82.

References

• IUBMB entry for 4.1.2.21
• BRENDA references for 4.1.2.21 (Recommended.)
• PubMed references for 4.1.2.21
• PubMed Central references for 4.1.2.21
• Google Scholar references for 4.1.2.21
• Shuster CW (1966). "2-Keto-3-deoxy-6-phosphogalactonic acid aldolase". Methods Enzymol. 9: 524–528. 

External links

The CAS registry number for this enzyme class is 9030-99-3.

• IUBMB entry for 4.1.2.21

• KEGG entry for 4.1.2.21

• BRENDA entry for 4.1.2.21

• NiceZyme view of 4.1.2.21

• EC2PDB: PDB structures for 4.1.2.21

• PRIAM entry for 4.1.2.21

• PUMA2 entry for 4.1.2.21

• IntEnz: Integrated Enzyme entry for 4.1.2.21

• MetaCyc entry for 4.1.2.21

• Atomic-resolution structures of enzymes belonging to this class

Gene Ontology (GO) codes

• EGO entry for GO code 0008674: 2-dehydro-3-deoxy-6-phosphogalactonate aldolase

• AMIGO entry for GO code 0008674: 2-dehydro-3-deoxy-6-phosphogalactonate aldolase