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2-chlorobenzoate 1,2-dioxygenase

In enzymology, a 2-chlorobenzoate 1,2-dioxygenase (EC 1.14.12.13) is an enzyme that catalyzes the chemical reaction

2-chlorobenzoate + NADH + H⁺ + O₂ catechol + chloride + NAD⁺ + CO₂

The 4 substrates of this enzyme are 2-chlorobenzoate, NADH, H⁺, and O₂, whereas its 4 products are catechol, chloride, NAD⁺, and CO₂.

This enzyme belongs to the family of oxidoreductases, specifically those acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derived from O2 with NADH or NADPH as one donor, and incorporation of two atoms o oxygen into the other donor. The systematic name of this enzyme class is 2-chlorobenzoate,NADH:oxygen oxidoreductase (1,2-hydroxylating, dechlorinating, decarboxylating). This enzyme is also called 2-halobenzoate 1,2-dioxygenase. This enzyme participates in benzoate degradation via coa ligation. It employs one cofactor, iron.

References

• IUBMB entry for 1.14.12.13
• BRENDA references for 1.14.12.13 (Recommended.)
• PubMed references for 1.14.12.13
• PubMed Central references for 1.14.12.13
• Google Scholar references for 1.14.12.13
• Fetzner S, Muller R, Lingens F (1989). "Degradation of 2-chlorobenzoate by Pseudomonas cepacia 2CBS". Biol. Chem. Hoppe. Seyler. 370: 1173–82. PMID 2610934. 

External links

The CAS registry number for this enzyme class is 125268-83-9.

• IUBMB entry for 1.14.12.13

• KEGG entry for 1.14.12.13

• BRENDA entry for 1.14.12.13

• NiceZyme view of 1.14.12.13

• EC2PDB: PDB structures for 1.14.12.13

• PRIAM entry for 1.14.12.13

• PUMA2 entry for 1.14.12.13

• IntEnz: Integrated Enzyme entry for 1.14.12.13

• MetaCyc entry for 1.14.12.13

• Atomic-resolution structures of enzymes belonging to this class

Gene Ontology (GO) codes

• EGO entry for GO code 0018626: 2-chlorobenzoate 1,2-dioxygenase

• AMIGO entry for GO code 0018626: 2-chlorobenzoate 1,2-dioxygenase