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2-chloro-4-carboxymethylenebut-2-en-1,4-olide isomerase

In enzymology, a 2-chloro-4-carboxymethylenebut-2-en-1,4-olide isomerase (EC 5.2.1.10) is an enzyme that catalyzes the chemical reaction

cis-2-chloro-4-carboxymethylenebut-2-en-1,4-olide trans-2-chloro-4-carboxymethylenebut-2-en-1,4-olide

Hence, this enzyme has one substrate, cis-2-chloro-4-carboxymethylenebut-2-en-1,4-olide, and one product, trans-2-chloro-4-carboxymethylenebut-2-en-1,4-olide.

This enzyme belongs to the family of isomerases, specifically cis-trans isomerases. The systematic name of this enzyme class is 2-chloro-4-carboxymethylenebut-2-en-1,4-olide cis-trans-isomerase. Other names in common use include 2-chlorocarboxymethylenebutenolide isomerase, and chlorodienelactone isomerase. This enzyme participates in 1,4-dichlorobenzene degradation.

References

• IUBMB entry for 5.2.1.10
• BRENDA references for 5.2.1.10 (Recommended.)
• PubMed references for 5.2.1.10
• PubMed Central references for 5.2.1.10
• Google Scholar references for 5.2.1.10
• Schwien U, Schmidt E, Knackmuss H-J and Reinecke W (1988). "Degradation of chlorosubstituted aromatic-compounds by Pseudomonas sp. strain-B13 - fate of 3,5-dichlorocatechol". Arch. Microbiol. 150: 78–84. doi:10.1007/BF00409721. 

External links

The CAS registry number for this enzyme class is 115629-29-3.

• IUBMB entry for 5.2.1.10

• KEGG entry for 5.2.1.10

• BRENDA entry for 5.2.1.10

• NiceZyme view of 5.2.1.10

• EC2PDB: PDB structures for 5.2.1.10

• PRIAM entry for 5.2.1.10

• PUMA2 entry for 5.2.1.10

• IntEnz: Integrated Enzyme entry for 5.2.1.10

• MetaCyc entry for 5.2.1.10

• Atomic-resolution structures of enzymes belonging to this class

Gene Ontology (GO) codes

• EGO entry for GO code 0047466: 2-chloro-4-carboxymethylenebutwtflongasswordidontthinkitshumantounderstandwtfthiswordmeanscansum1pleaseexplainittome?-2-en-1,4-olide isomerase

• AMIGO entry for GO code 0047466: 2-chloro-4-carboxymethylenebutwtflongasswordidontthinkitshumantounderstandwtfthiswordmeanscansum1pleaseexplainittome?-2-en-1,4-olide isomerase