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1-phosphatidylinositol 4-kinase

In enzymology, a 1-phosphatidylinositol 4-kinase (EC 2.7.1.67) is an enzyme that catalyzes the chemical reaction

ATP + 1-phosphatidyl-1D-myo-inositol ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate

Thus, the two substrates of this enzyme are ATP and 1-phosphatidyl-1D-myo-inositol, whereas its two products are ADP and 1-phosphatidyl-1D-myo-inositol 4-phosphate.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor. The systematic name of this enzyme class is ATP:1-phosphatidyl-1D-myo-inositol 4-phosphotransferase. Other names in common use include phosphatidylinositol kinase (phosphorylating), phosphatidylinositol 4-kinase, phosphatidylinositol kinase, type II phosphatidylinositol kinase, PI kinase, and PI 4-kinase. This enzyme participates in inositol phosphate metabolism and phosphatidylinositol signaling system.

Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 2JU0.

References

• IUBMB entry for 2.7.1.67
• BRENDA references for 2.7.1.67 (Recommended.)
• PubMed references for 2.7.1.67
• PubMed Central references for 2.7.1.67
• Google Scholar references for 2.7.1.67
• Colodzin M, Kennedy EP (1965). "Biosynthesis of diphosphoinositide in brain". J. Biol. Chem. 240: 3771–80. PMID 4284712. 
• Kai M, White GL, Hawthorne JN (1966). "The phosphatidylinositol kinase of rat brain". Biochem. J. 101: 328–37. PMID 4290722. 
• Walker DH, Dougherty N, Pike LJ (1988). "Purification and characterization of a phosphatidylinositol kinase from A431 cells". Biochemistry. 27: 6504–11. doi:10.1021/bi00417a046. PMID 2851325. 
• Whitman M, Downes CP, Keeler M, Keller T, Cantley L (1988). "Type I phosphatidylinositol kinase makes a novel inositol phospholipid, phosphatidylinositol-3-phosphate". Nature. 332: 644–6. doi:10.1038/332644a0. PMID 2833705. 
• Albanesi JP (2001). "A novel family of phosphatidylinositol 4-kinases conserved from yeast to humans". J. Biol. Chem. 276: 7705–8. doi:10.1074/jbc.C000861200. PMID 11244087. 

External links

The CAS registry number for this enzyme class is 37205-54-2.

• IUBMB entry for 2.7.1.67

• KEGG entry for 2.7.1.67

• BRENDA entry for 2.7.1.67

• NiceZyme view of 2.7.1.67

• EC2PDB: PDB structures for 2.7.1.67

• PRIAM entry for 2.7.1.67

• PUMA2 entry for 2.7.1.67

• IntEnz: Integrated Enzyme entry for 2.7.1.67

• MetaCyc entry for 2.7.1.67

• Atomic-resolution structures of enzymes belonging to this class

Gene Ontology (GO) codes

• EGO entry for GO code 0004430: 1-phosphatidylinositol 4-kinase

• AMIGO entry for GO code 0004430: 1-phosphatidylinositol 4-kinase