Home › Multilingual Archive Index › 1-phosphatidylinositol-5-phosphate 4-kinase

1-phosphatidylinositol-5-phosphate 4-kinase

In enzymology, a 1-phosphatidylinositol-5-phosphate 4-kinase (EC 2.7.1.149) is an enzyme that catalyzes the chemical reaction

ATP + 1-phosphatidyl-1D-myo-inositol 5-phosphate ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate

Thus, the two substrates of this enzyme are ATP and 1-phosphatidyl-1D-myo-inositol 5-phosphate, whereas its two products are ADP and 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor. The systematic name of this enzyme class is ATP:1-phosphatidyl-1D-myo-inositol-5-phosphate 4-phosphotransferase. This enzyme is also called type II PIP kinase. This enzyme participates in 3 metabolic pathways: inositol phosphate metabolism, phosphatidylinositol signaling system, and regulation of actin cytoskeleton.

References

• IUBMB entry for 2.7.1.149
• BRENDA references for 2.7.1.149 (Recommended.)
• PubMed references for 2.7.1.149
• PubMed Central references for 2.7.1.149
• Google Scholar references for 2.7.1.149
• Rameh LE, Tolias KF, Duckworth BC, Cantley LC (1997). "A new pathway for synthesis of phosphatidylinositol-4,5-bisphosphate". Nature. 390: 192–6. doi:10.1038/36621. PMID 9367159. 

External links

• IUBMB entry for 2.7.1.149

• KEGG entry for 2.7.1.149

• BRENDA entry for 2.7.1.149

• NiceZyme view of 2.7.1.149

• EC2PDB: PDB structures for 2.7.1.149

• PRIAM entry for 2.7.1.149

• PUMA2 entry for 2.7.1.149

• IntEnz: Integrated Enzyme entry for 2.7.1.149

• MetaCyc entry for 2.7.1.149

• Atomic-resolution structures of enzymes belonging to this class

Gene Ontology (GO) codes

• EGO entry for GO code 0016309: 1-phosphatidylinositol-5-phosphate 4-kinase

• AMIGO entry for GO code 0016309: 1-phosphatidylinositol-5-phosphate 4-kinase