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1-phosphatidylinositol-3-phosphate 5-kinase

In enzymology, a 1-phosphatidylinositol-3-phosphate 5-kinase (EC 2.7.1.150) is an enzyme that catalyzes the chemical reaction

ATP + 1-phosphatidyl-1D-myo-inositol 3-phosphate ADP + 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate

Thus, the two substrates of this enzyme are ATP and 1-phosphatidyl-1D-myo-inositol 3-phosphate, whereas its two products are ADP and 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor. The systematic name of this enzyme class is ATP:1-phosphatidyl-1D-myo-inositol-3-phosphate 5-phosphotransferase. Other names in common use include type III PIP kinase, and phosphatidylinositol 3-phosphate 5-kinase. This enzyme participates in phosphatidylinositol signaling system and regulation of actin cytoskeleton.

References

• IUBMB entry for 2.7.1.150
• BRENDA references for 2.7.1.150 (Recommended.)
• PubMed references for 2.7.1.150
• PubMed Central references for 2.7.1.150
• Google Scholar references for 2.7.1.150
• RH, Parker PJ (1998). "The stress-activated phosphatidylinositol 3-phosphate 5-kinase Fab1p is essential for vacuole function in S. cerevisiae". Curr. Biol. 8: 1219–22. doi:10.1016/S0960-9822(07)00513-1. PMID 9811604. 

External links

• IUBMB entry for 2.7.1.150

• KEGG entry for 2.7.1.150

• BRENDA entry for 2.7.1.150

• NiceZyme view of 2.7.1.150

• EC2PDB: PDB structures for 2.7.1.150

• PRIAM entry for 2.7.1.150

• PUMA2 entry for 2.7.1.150

• IntEnz: Integrated Enzyme entry for 2.7.1.150

• MetaCyc entry for 2.7.1.150

• Atomic-resolution structures of enzymes belonging to this class

Gene Ontology (GO) codes

• EGO entry for GO code 0000285: 1-phosphatidylinositol-3-phosphate 5-kinase

• AMIGO entry for GO code 0000285: 1-phosphatidylinositol-3-phosphate 5-kinase