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1-alkyl-2-acetylglycerophosphocholine esterase

In enzymology, a 1-alkyl-2-acetylglycerophosphocholine esterase (EC 3.1.1.47) is an enzyme that catalyzes the chemical reaction

1-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H₂O 1-alkyl-sn-glycero-3-phosphocholine + acetate

Thus, the two substrates of this enzyme are 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine and H₂O, whereas its two products are 1-alkyl-sn-glycero-3-phosphocholine and acetate.

This enzyme belongs to the family of hydrolases, specifically those acting on carboxylic ester bonds. The systematic name of this enzyme class is 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine acetohydrolase. Other names in common use include 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine acetylhydrolase, and alkylacetyl-GPC:acetylhydrolase. This enzyme participates in ether lipid metabolism.

Structural studies

As of late 2007, 7 structures have been solved for this class of enzymes, with PDB accession codes 1BWP, 1BWQ, 1BWR, 1ES9, 1FXW, 1VYH, and 1WAB.

References

• IUBMB entry for 3.1.1.47
• BRENDA references for 3.1.1.47 (Recommended.)
• PubMed references for 3.1.1.47
• PubMed Central references for 3.1.1.47
• Google Scholar references for 3.1.1.47
• Blank ML, Lee T, Fitzgerald V, Snyder F (1981). "A specific acetylhydrolase for 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine (a hypotensive and platelet-activating lipid)". J. Biol. Chem. 256: 175–8. PMID 7451433. 

External links

The CAS registry number for this enzyme class is 76901-00-3.

• IUBMB entry for 3.1.1.47

• KEGG entry for 3.1.1.47

• BRENDA entry for 3.1.1.47

• NiceZyme view of 3.1.1.47

• EC2PDB: PDB structures for 3.1.1.47

• PRIAM entry for 3.1.1.47

• PUMA2 entry for 3.1.1.47

• IntEnz: Integrated Enzyme entry for 3.1.1.47

• MetaCyc entry for 3.1.1.47

• Atomic-resolution structures of enzymes belonging to this class

Gene Ontology (GO) codes

• EGO entry for GO code 0003847: 1-alkyl-2-acetylglycerophosphocholine esterase

• AMIGO entry for GO code 0003847: 1-alkyl-2-acetylglycerophosphocholine esterase