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1-Pyrroline-5-carboxylate dehydrogenase

In enzymology, a 1-pyrroline-5-carboxylate dehydrogenase (EC 1.5.1.12) is an enzyme that catalyzes the chemical reaction

(S)-1-pyrroline-5-carboxylate + NAD⁺ + 2 H₂O L-glutamate + NADH + H⁺

The three substrates of this enzyme are (S)-1-pyrroline-5-carboxylate, NAD⁺, and H₂O, whereas its three products are glutamate, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH group of donors with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (S)-1-pyrroline-5-carboxylate:NAD⁺ oxidoreductase. Other names in common use include delta-1-pyrroline-5-carboxylate dehydrogenase, 1-pyrroline dehydrogenase, pyrroline-5-carboxylate dehydrogenase, pyrroline-5-carboxylic acid dehydrogenase, L-pyrroline-5-carboxylate-NAD⁺ oxidoreductase, and 1-pyrroline-5-carboxylate:NAD⁺ oxidoreductase. This enzyme participates in glutamate metabolism and arginine and proline metabolism.

Structural studies

As of late 2007, 14 structures have been solved for this class of enzymes, with PDB accession codes 2BHP, 2BHQ, 2BJA, 2BJK, 2EHQ, 2EHU, 2EII, 2EIT, 2EIW, 2EJ6, 2EJD, 2EJL, 2IY6, and 2J40.

References

• IUBMB entry for 1.5.1.12
• BRENDA references for 1.5.1.12 (Recommended.)
• PubMed references for 1.5.1.12
• PubMed Central references for 1.5.1.12
• Google Scholar references for 1.5.1.12
• Adams E and Goldstone A (1960). "Hydroxyproline metabolism. IV. Enzymatic synthesis of gamma-hydroxyglutamate from Delta1-pyrroline-3-hydroxy-5-carboxylate". J. Biol. Chem. 235: 3504–3512. 
• Strecker HJ (1960). "The interconversion of glutamic acid and proline. III Delta1-Pyrroline-5-carboxylic acid dehydrogenase". J. Biol. Chem. 235: 3218–3223. 

External links

The CAS registry number for this enzyme class is 9054-82-4.

• IUBMB entry for 1.5.1.12

• KEGG entry for 1.5.1.12

• BRENDA entry for 1.5.1.12

• NiceZyme view of 1.5.1.12

• EC2PDB: PDB structures for 1.5.1.12

• PRIAM entry for 1.5.1.12

• PUMA2 entry for 1.5.1.12

• IntEnz: Integrated Enzyme entry for 1.5.1.12

• MetaCyc entry for 1.5.1.12

• Atomic-resolution structures of enzymes belonging to this class

Gene Ontology (GO) codes

• EGO entry for GO code 0003842: 1-pyrroline-5-carboxylate dehydrogenase

• AMIGO entry for GO code 0003842: 1-pyrroline-5-carboxylate dehydrogenase