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(S)-coclaurine-N-methyltransferase

In enzymology, a (S)-coclaurine-N-methyltransferase (EC 2.1.1.140) is an enzyme that catalyzes the chemical reaction

S-adenosyl-L-methionine + (S)-coclaurine S-adenosyl-L-homocysteine + (S)-N-methylcoclaurine

Thus, the two substrates of this enzyme are S-adenosyl methionine and (S)-coclaurine, whereas its two products are S-adenosylhomocysteine and (S)-N-methylcoclaurine.

This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:(S)-coclaurine-N-methyltransferase. This enzyme participates in alkaloid biosynthesis i.

References

• IUBMB entry for 2.1.1.140
• BRENDA references for 2.1.1.140 (Recommended.)
• PubMed references for 2.1.1.140
• PubMed Central references for 2.1.1.140
• Google Scholar references for 2.1.1.140
• Loeffler S, Deus-Neumann B and Zenk MH (1995). "S-Adenosyl-L-methionine: (S)-coclaurine-N-methyltransferase from Tinospora cordifolia". Phytochemistry 38: 1387–1395. doi:10.1016/0031-9422(94)00813-9. 

External links

• IUBMB entry for 2.1.1.140

• KEGG entry for 2.1.1.140

• BRENDA entry for 2.1.1.140

• NiceZyme view of 2.1.1.140

• EC2PDB: PDB structures for 2.1.1.140

• PRIAM entry for 2.1.1.140

• PUMA2 entry for 2.1.1.140

• IntEnz: Integrated Enzyme entry for 2.1.1.140

• MetaCyc entry for 2.1.1.140

• Atomic-resolution structures of enzymes belonging to this class

Gene Ontology (GO) codes

• EGO entry for GO code 0030794: (S)-coclaurine-N-methyltransferase

• AMIGO entry for GO code 0030794: (S)-coclaurine-N-methyltransferase