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(S)-N-acetyl-1-phenylethylamine hydrolase

In enzymology, a (S)-N-acetyl-1-phenylethylamine hydrolase (EC 3.5.1.85) is an enzyme that catalyzes the chemical reaction

N-acetylphenylethylamine + H₂O phenylethylamine + acetate

Thus, the two substrates of this enzyme are N-acetylphenylethylamine and H₂O, whereas its two products are phenylethylamine and acetate.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in linear amides. The systematic name of this enzyme class is (S)-N-acetylphenylethylamine:H2O hydrolase. At least one compound, Phenylmethanesulfonyl fluoride is known to inhibit this enzyme.

References

• IUBMB entry for 3.5.1.85
• BRENDA references for 3.5.1.85 (Recommended.)
• PubMed references for 3.5.1.85
• PubMed Central references for 3.5.1.85
• Google Scholar references for 3.5.1.85
• Brunella A, Graf M, Kittelmann M, Lauma K and Ghisalba O (1997). "Production, purification, and characterization of a highly enantioselective (S)-N-acetyl-1-phenylethyl amidohydrolase from Rhodococcus". Appl. Microbiol. Biotechnol. 47: 515–520. doi:10.1007/s002530050965. 

External links

The CAS registry number for this enzyme class is 192230-94-7.

• IUBMB entry for 3.5.1.85

• KEGG entry for 3.5.1.85

• BRENDA entry for 3.5.1.85

• NiceZyme view of 3.5.1.85

• EC2PDB: PDB structures for 3.5.1.85

• PRIAM entry for 3.5.1.85

• PUMA2 entry for 3.5.1.85

• IntEnz: Integrated Enzyme entry for 3.5.1.85

• MetaCyc entry for 3.5.1.85

• Atomic-resolution structures of enzymes belonging to this class

Gene Ontology (GO) codes

• EGO entry for GO code 0050536: (S)-N-acetyl-1-phenylethylamine hydrolase

• AMIGO entry for GO code 0050536: (S)-N-acetyl-1-phenylethylamine hydrolase