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(S)-6-hydroxynicotine oxidase

In enzymology, a (S)-6-hydroxynicotine oxidase (EC 1.5.3.5) is an enzyme that catalyzes the chemical reaction

(S)-6-hydroxynicotine + H₂O + O₂ 1-(6-hydroxypyridin-3-yl)-4-(methylamino)butan-1-one + H₂O₂

The 3 substrates of this enzyme are (S)-6-hydroxynicotine, H₂O, and O₂, whereas its two products are 1-(6-hydroxypyridin-3-yl)-4-(methylamino)butan-1-one and H₂O₂.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH group of donors with oxygen as acceptor. The systematic name of this enzyme class is (S)-6-hydroxynicotine:oxygen oxidoreductase. Other names in common use include L-6-hydroxynicotine oxidase, 6-hydroxy-L-nicotine oxidase, and 6-hydroxy-L-nicotine:oxygen oxidoreductase. It employs one cofactor, FAD.

References

• IUBMB entry for 1.5.3.5
• BRENDA references for 1.5.3.5 (Recommended.)
• PubMed references for 1.5.3.5
• PubMed Central references for 1.5.3.5
• Google Scholar references for 1.5.3.5
• Dai VD, Decker K, Sund H (1968). "Purification and properties of L-6-hydroxynicotine oxidase". Eur. J. Biochem. 4: 95–102. doi:10.1111/j.1432-1033.1968.tb00177.x. PMID 5646150. 
• Decker K, Bleeg H (1965). "Induction and purification of stereospecific nicotine oxidizing enzymes from Arthrobacter oxidans". Biochim. Biophys. Acta. 105: 313–24. PMID 5849820. 

External links

The CAS registry number for this enzyme class is 37256-29-4.

• IUBMB entry for 1.5.3.5

• KEGG entry for 1.5.3.5

• BRENDA entry for 1.5.3.5

• NiceZyme view of 1.5.3.5

• EC2PDB: PDB structures for 1.5.3.5

• PRIAM entry for 1.5.3.5

• PUMA2 entry for 1.5.3.5

• IntEnz: Integrated Enzyme entry for 1.5.3.5

• MetaCyc entry for 1.5.3.5

• Atomic-resolution structures of enzymes belonging to this class

Gene Ontology (GO) codes

• EGO entry for GO code 0018531: (S)-6-hydroxynicotine oxidase

• AMIGO entry for GO code 0018531: (S)-6-hydroxynicotine oxidase