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(S)-3-hydroxyacid-ester dehydrogenase

In enzymology, a (S)-3-hydroxyacid-ester dehydrogenase (EC 1.1.1.280) is an enzyme that catalyzes the chemical reaction

ethyl (S)-3-hydroxyhexanoate + NADP⁺ ethyl 3-oxohexanoate + NADPH + H⁺

Thus, the two substrates of this enzyme are ethyl (S)-3-hydroxyhexanoate and NADP⁺, whereas its 3 products are ethyl 3-oxohexanoate, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is ethyl-(S)-3-hydroxyhexanoate:NADP+ 3-oxidoreductase. This enzyme is also called 3-oxo ester (S)-reductase.

References

• IUBMB entry for 1.1.1.280
• BRENDA references for 1.1.1.280 (Recommended.)
• PubMed references for 1.1.1.280
• PubMed Central references for 1.1.1.280
• Google Scholar references for 1.1.1.280
• Heidlas J, Engel KH, Tressl R (1988). "Purification and characterization of two oxidoreductases involved in the enantioselective reduction of 3-oxo, 4-oxo and 5-oxo esters in baker's yeast". Eur. J. Biochem. 172: 633–9. doi:10.1111/j.1432-1033.1988.tb13936.x. PMID 3280313. 

External links

The CAS registry number for this enzyme class is 114705-03-2.

• IUBMB entry for 1.1.1.280

• KEGG entry for 1.1.1.280

• BRENDA entry for 1.1.1.280

• NiceZyme view of 1.1.1.280

• EC2PDB: PDB structures for 1.1.1.280

• PRIAM entry for 1.1.1.280

• PUMA2 entry for 1.1.1.280

• IntEnz: Integrated Enzyme entry for 1.1.1.280

• MetaCyc entry for 1.1.1.280

• Atomic-resolution structures of enzymes belonging to this class

Gene Ontology (GO) codes

• EGO entry for GO code 0047109: (S)-3-hydroxyacid-ester dehydrogenase

• AMIGO entry for GO code 0047109: (S)-3-hydroxyacid-ester dehydrogenase